Neo-Triple Helix Model of Innovation Ecosystems: Integrating Triple, Quadruple and Quintuple Helix Models

Abstract This article proposes the neo-Triple Helix model of innovation ecosystems by integrating Triple, Quadruple and Quintuple models, inspired Lewontin’s gene, organism environment Triple metaphor. The considers evolved through interactions between 1) dynamics (or genes), 2) social structures 3) natural environment. systems include two-layer triple helix triads): university, industry government at gene level, genes, system level. Innovation are conceptualised neo-institutional neo-evolutionary perspectives model. dialectical relationships primarily explained using aspects models. clarifies debates on different advances helical approaches synergy building can guide empirical research policy design ecosystems.